Drug General Information |
Drug ID |
D0T4SJ
|
Former ID |
DIB006557
|
Drug Name |
SCH-546909
|
Synonyms |
CDK2 inhibitors (cancer); SCH-546909; CDK2 inhibitors (cancer), Merck & Co; CDK2 inhibitors (cancer), Schering-Plough; Cyclindependent kinase 2 inhibitors (cancer), Schering-Plough
|
Drug Type |
Small molecular drug
|
Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
|
Investigative |
[1]
|
Company |
Schering-Plough Corp
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C16H11NO4
|
Canonical SMILES |
c12c3c4c(cc1[nH]c(=O)c2cc(c3OC)O)ccc(c4)O
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Cell division protein kinase 2 |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
FoxO signaling pathway
|
Cell cycle
|
Oocyte meiosis
|
p53 signaling pathway
|
PI3K-Akt signaling pathway
|
Progesterone-mediated oocyte maturation
|
Hepatitis B
|
Measles
|
Herpes simplex infection
|
Epstein-Barr virus infection
|
Pathways in cancer
|
Viral carcinogenesis
|
Prostate cancer
|
Small cell lung cancer
|
NetPath Pathway
|
TCR Signaling Pathway
|
PANTHER Pathway
|
p53 pathway
|
p53 pathway feedback loops 2
|
Pathway Interaction Database
|
Regulation of nuclear SMAD2/3 signaling
|
Signaling events mediated by PRL
|
p73 transcription factor network
|
E2F transcription factor network
|
ATR signaling pathway
|
mTOR signaling pathway
|
IL2-mediated signaling events
|
FoxO family signaling
|
FOXM1 transcription factor network
|
BARD1 signaling events
|
p53 pathway
|
Regulation of retinoblastoma protein
|
Reactome
|
G0 and Early G1
|
Activation of ATR in response to replication stress
|
Regulation of APC/C activators between G1/S and early anaphase
|
SCF(Skp2)-mediated degradation of p27/p21
|
Senescence-Associated Secretory Phenotype (SASP)
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DNA Damage/Telomere Stress Induced Senescence
|
Processing of DNA double-strand break ends
|
G2 Phase
|
Orc1 removal from chromatin
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Cyclin E associated events during G1/S transition
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Cyclin A/B1 associated events during G2/M transition
|
p53-Dependent G1 DNA Damage Response
|
Cyclin A:Cdk2-associated events at S phase entry
|
Meiotic recombination
|
Factors involved in megakaryocyte development and platelet production
|
WikiPathways
|
DNA Damage Response
|
ID signaling pathway
|
DNA Replication
|
G1 to S cell cycle control
|
M/G1 Transition
|
S Phase
|
Meiotic Recombination
|
Aryl Hydrocarbon Receptor
|
ATM Signaling Pathway
|
Retinoblastoma (RB) in Cancer
|
Spinal Cord Injury
|
Integrated Pancreatic Cancer Pathway
|
Oncostatin M Signaling Pathway
|
Prostate Cancer
|
Signaling Pathways in Glioblastoma
|
TSH signaling pathway
|
Integrated Breast Cancer Pathway
|
Integrated Cancer pathway
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Synthesis of DNA
|
Regulation of DNA replication
|
Mitotic G2-G2/M phases
|
Mitotic G1-G1/S phases
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Factors involved in megakaryocyte development and platelet production
|
Cell Cycle
|
APC/C-mediated degradation of cell cycle proteins
|
Cell Cycle Checkpoints
|
miRNA Regulation of DNA Damage Response
|
References |
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1973). |