Drug General Information
Drug ID	D0T5MB
Former ID	DIB015358
Drug Name	Lu-35138
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Discontinued in Phase 2	[547224]
Company	H Lundbeck A/S
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1N(c2c([C@@H]1CCC1CC(=CCN1)c1c[nH]c3c1ccc(c3)Cl)cccc2)<br />C(=O)C
Target and Pathway
Target(s)	D(4) dopamine receptor	Target Info	Antagonist	[547225]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Dopaminergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, Other
References
Ref 547224	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014237)
Ref 547225	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014237)

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