TTD | Drug: D0T6TH

Drug General Information
Drug ID	D0T6TH
Former ID	DIB001468
Drug Name	EVT-501
Synonyms	H3 antagonists (cognitive/sleep disorders), Evotec
Indication	Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47]		Investigative	[543673]
Company	Evotec AG
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Antagonist	[543673]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
Reactome	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543673	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264).
Ref 543673	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264).

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Drug Information