Drug General Information
Drug ID	D0T8KF
Former ID	DIB013102
Drug Name	SUN-8399
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Discontinued in Phase 1	[544893]
Company	Suntory Ltd
Structure		Download 2D MOL 3D MOL
Formula	C21H25N5O3
Canonical SMILES	C1(=O)N(C(=O)COc2c1cccc2)CCCCN1CCN(c2ncccn2)CC1
CAS Number	CAS 131112-58-8
PubChem Compound ID	131339
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Agonist	[533869]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544893	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001433)
Ref 533869	Effects of SUN 8399, a potent and selective 5-HT1A agonist, on conflict behavior and ambulatory activity in mice: comparison with those of buspirone, tandospirone and diazepam. Jpn J Pharmacol. 1994 Apr;64(4):273-80.

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