Drug Information

Drug General Information
Drug ID
D0T8KR
Former ID
DNC014447
Drug Name
TWS-119
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541253]
Structure
Download
2D MOL

3D MOL
Formula
C18H14N4O2
InChI
InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChIKey
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
PubChem Compound ID
9549289
PubChem Substance ID
14720344, 14776903, 23984865, 26758807, 44692618, 48020050, 53800752, 80348364, 85787226, 91136600, 99302806, 103567441, 104253237, 123105101, 125335707, 134351652, 134964443, 136348261, 136367556, 136367744, 139797663, 152258259, 152344232, 160647095, 162011851, 162038068, 162202791, 163125997, 163688036, 165247649, 170497643, 170500656, 172919793, 174006978, 174529960, 175607483, 178102603, 179230462, 186005333, 204371598, 208264968, 218926473, 223399381, 223705086, 223925632, 231373952, 242060077, 244956719, 247953237, 249755532
Target and Pathway
Target(s) Myc proto-oncogene protein Target Info Inhibitor [527964]
Glycogen synthase kinase-3 beta Target Info Inhibitor [527964]
Transcription factor AP-1 Target Info Inhibitor [527964]
KEGG Pathway MAPK signaling pathway
ErbB signaling pathway
Cell cycle
PI3K-Akt signaling pathway
Wnt signaling pathway
TGF-beta signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Thyroid hormone signaling pathway
Hepatitis B
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Endometrial cancer
Thyroid cancer
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Central carbon metabolism in cancerhsa04012:ErbB signaling pathway
Chemokine signaling pathway
Hedgehog signaling pathway
Axon guidance
Focal adhesion
T cell receptor signaling pathway
B cell receptor signaling pathway
Neurotrophin signaling pathway
Dopaminergic synapse
Insulin signaling pathway
Melanogenesis
Prolactin signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Hepatitis C
Measles
Influenza A
Prostate cancer
Basal cell carcinomahsa04010:MAPK signaling pathway
cAMP signaling pathway
Osteoclast differentiation
Toll-like receptor signaling pathway
TNF signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Oxytocin signaling pathway
Cocaine addiction
Amphetamine addiction
Epithelial cell signaling in Helicobacter pylori infection
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Herpes simplex infection
Viral carcinogenesis
Renal cell carcinoma
Choline metabolism in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
NetPath Pathway IL9 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Notch Signaling Pathway
Wnt Signaling Pathway
TSH Signaling PathwayNetPath_19:IL-7 Signaling Pathway
IL1 Signaling Pathway
TSH Signaling Pathway
AndrogenReceptor Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Oxidative stress response
PDGF signaling pathway
Wnt signaling pathway
p53 pathway feedback loops 2
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Angiogenesis
Cadherin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
PI3 kinase pathway
Ras Pathway
CCKR signaling map STP00005:Angiogenesis
Apoptosis signaling pathway
B cell activation
FAS signaling pathway
Huntington disease
Inflammation mediated by chemokine and cytokine signaling pathway
TGF-beta signaling pathway
T cell activation
Toll receptor signaling pathway
CCKR signaling map ST
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Notch signaling pathway
p73 transcription factor network
E2F transcription factor network
CD40/CD40L signaling
Validated targets of C-MYC transcriptional activation
Presenilin action in Notch and Wnt signaling
LKB1 signaling events
Regulation of Telomerase
IL2-mediated signaling events
C-MYC pathway
IL2 signaling events mediated by PI3K
Ceramide signaling pathway
AP-1 transcription factor network
FOXM1 transcription factor network
IL6-mediated signaling events
PDGFR-beta signaling pathway
C-MYB transcription factor network
Validated nuclear estrogen receptor alpha network
Regulation of nuclear beta catenin signaling and target gene transcription
IL2 signaling events mediated by STAT5
Validated targets of C-MYC transcriptional repressionlysophospholipid_pathway:LPA receptor mediated events
Degradation of beta catenin
Reelin signaling pathway
Integrin-linked kinase signaling
CDC42 signaling events
Canonical Wnt signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
BMP receptor signaling
Hedgehog signaling events mediated by Gli proteins
Signaling events mediated by Stem cell factor receptor (c-Kit)
Validated transcriptional targets of deltaNp63 isoforms
Aurora A signaling
Insulin-mediated glucose transport
Class I PI3K signaling events mediated by Akt
p53 pathway
Trk receptor signaling mediated by PI3K and PLC-gammasmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Fc-epsilon receptor I signaling in mast cells
Endothelins
BCR signaling pathway
RhoA signaling pathway
LPA receptor mediated events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Signaling events regulated by Ret tyrosine kinase
IL1-mediated signaling events
Direct p53 effectors
ErbB1 downstream signaling
ATF-2 transcription factor network
ErbB2/ErbB3 signaling events
JNK signaling in the CD4+ TCR pathway
Nephrin/Neph1 signaling in the kidney podocyte
PDGFR-alpha signaling pathway
Signaling mediated by p38-alpha and p38-beta
Calcium signaling in the CD4+ TCR pathway
HIF-1-alpha transcription factor network
S1P2 pathway
Downstream signaling in na&#xef
FGF signaling pathway
RAC1 signaling pathway
Regulation of retinoblastoma protein
Signaling events mediated by focal adhesion kinase
FOXA1 transcription factor network
IL12 signaling mediated by STAT4
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome NOTCH1 Intracellular Domain Regulates Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Binding of TCF/LEF:CTNNB1 to target gene promoters
MAPK6/MAPK4 signaling
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entryR-HSA-195253:Degradation of beta-catenin by the destruction complex
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
Degradation of GLI2 by the proteasome
Constitutive Signaling by AKT1 E17K in CancerR-HSA-1912408:Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
WikiPathways DNA Damage Response (only ATM dependent)
DNA Damage Response
ErbB Signaling Pathway
Notch Signaling Pathway
IL-2 Signaling Pathway
G1 to S cell cycle control
Wnt Signaling Pathway
p38 MAPK Signaling Pathway
Wnt Signaling Pathway and Pluripotency
MAPK Signaling Pathway
TGF beta Signaling Pathway
Wnt Signaling Pathway Netpath
PPAR Alpha Pathway
Ectoderm Differentiation
Hair Follicle Development: Organogenesis (Part 2 of 3)
Bladder Cancer
Mammary gland development pathway - Involution (Stage 4 of 4)
Hair Follicle Development: Induction (Part 1 of 3)
S Phase
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Signaling by NOTCH1
Structural Pathway of Interleukin 1 (IL-1)
Aryl Hydrocarbon Receptor
Polycystic Kidney Disease Pathway
Apoptosis
Retinoblastoma (RB) in Cancer
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Gastric cancer network 2
B Cell Receptor Signaling Pathway
Prostate Cancer
Metastatic brain tumor
TSLP Signaling Pathway
Neural Crest Differentiation
IL-7 Signaling Pathway
TSH signaling pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Mitotic G1-G1/S phases
TP53 Network
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
IL-5 Signaling PathwayWP710:DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Glycogen Metabolism
Insulin Signaling
IL-6 signaling pathway
Copper homeostasis
Focal Adhesion
Cardiac Hypertrophic Response
Degradation of beta-catenin by the destruction complex
T-Cell Receptor and Co-stimulatory Signaling
Cardiac Progenitor Differentiation
BDNF signaling pathway
Corticotropin-releasing hormone
IL17 signaling pathway
Alzheimers Disease
Regulation of Microtubule Cytoskeleton
TWEAK Signaling Pathway
Leptin signaling pathway
Semaphorin interactions
Cell Cycle
MicroRNAs in cardiomyocyte hypertrophy
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP75:Toll-like receptor signaling pathway
Estrogen signaling pathway
SIDS Susceptibility Pathways
TCR Signaling Pathway
TGF Beta Signaling Pathway
EGF/EGFR Signaling Pathway
MAPK Cascade
FAS pathway and Stress induction of HSP regulation
Signaling of Hepatocyte Growth Factor Receptor
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Aryl Hydrocarbon Receptor Pathway
IL-3 Signaling Pathway
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Selenium Metabolism and Selenoproteins
Pre-NOTCH Expression and Processing
Fc epsilon receptor (FCERI) signaling
PDGF Pathway
ATM Signaling Pathway
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
AGE/RAGE pathway
TNF alpha Signaling Pathway
Arylhydrocarbon receptor (AhR) signaling pathway
RANKL/RANK Signaling Pathway
IL-1 signaling pathway
MAPK targets/ Nuclear events mediated by MAP kinases
Apoptosis Modulation and Signaling
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathway
IL-5 Signaling Pathway
References
Ref 541253(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5980).
Ref 527964Nat Chem Biol. 2005 Jul;1(2):74-84.Diversity-oriented synthesis: exploring the intersections between chemistry and biology.

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