Drug Information

Drug General Information
Drug ID
D0T8QB
Former ID
DNC010571
Drug Name
GLYCYRRHIZIN
Drug Type
Small molecular drug
Indication Influenza virus [ICD10:J11.1] Phase 3 [467927], [523449]
Structure
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2D MOL

3D MOL
Formula
C42H62O16
InChI
InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+/m0/s1
InChIKey
LPLVUJXQOOQHMX-QWBHMCJMSA-N
PubChem Compound ID
14982
PubChem Substance ID
595979, 8145710, 8161234, 12014953, 14767124, 14889369, 29282971, 49974013, 53789412, 57328816, 80458755, 87570348, 93165815, 104069368, 104225159, 104253562, 104335876, 117542241, 118046163, 119525684, 124360077, 124757704, 125164508, 126592383, 134981322, 135985736, 137005264, 137174069, 144205073, 144206976, 144213802, 152032505, 152108764, 160703999, 162037865, 162176852, 163614442, 163883554, 175265976, 178101402, 179316054, 184545284, 196378207, 223673136, 223721543, 223800488, 226407764, 249839445, 252216692, 252391202
SuperDrug ATC ID
A05BA08
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [530246]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 467927(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4688).
Ref 523449ClinicalTrials.gov (NCT01342185) Efficacy of Medical Ozone Therapy in Patients With Chronic Hepatitis B. U.S. National Institutes of Health.
Ref 530246Bioorg Med Chem. 2009 Aug 1;17(15):5722-32. Epub 2009 Jun 12.Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes.

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