Drug Information

Drug General Information
Drug ID
D0T8YV
Former ID
DIB003683
Drug Name
LymphoRad-131
Synonyms
Ardenermin; LymphoRad; LR-131; Radiolabeled BLyS protein, HGS; Radiolabeled ardenermine, HGS
Indication Lymphoma [ICD9: 202.8, 208.9; ICD10:C81-C86] Discontinued in Phase 1 [547502]
Company
Human Genome Sciences Inc
Target and Pathway
Target(s) Tumor necrosis factor ligand superfamily member 13B Target Info Modulator [544263]
KEGG Pathway Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Intestinal immune network for IgA production
Rheumatoid arthritis
Reactome TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
WikiPathways Spinal Cord Injury
References
Ref 547502Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016875)
Ref 544263Fusion Toxin BLyS-Gelonin Inhibits Growth of Malignant Human B Cell Lines In Vitro and In Vivo. PLoS One. 2012; 7(10): e47361.

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