Drug General Information
Drug ID	D0TE6A
Former ID	DNC004291
Drug Name	1,5-Dihydro-imidazo[2,1-b]quinazolin-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533367]
Structure		Download 2D MOL 3D MOL
Formula	C10H9N3O
Canonical SMILES	C1C2=CC=CC=C2NC3=NC(=O)CN31
InChI	1S/C10H9N3O/c14-9-6-13-5-7-3-1-2-4-8(7)11-10(13)12-9/h1-4H,5-6H2,(H,11,12,14)
InChIKey	YLVVAWCDANPADI-UHFFFAOYSA-N
PubChem Compound ID	10130278
Target and Pathway
Target(s)	CGMP-inhibited 3',5'-cyclic phosphodiesterase A	Target Info	Inhibitor	[533367]
KEGG Pathway	Purine metabolism
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Morphine addiction
Reactome	cGMP effects
	G alpha (s) signalling events
WikiPathways	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
References
Ref 533367	J Med Chem. 1988 Nov;31(11):2136-45.Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.
Ref 533367	J Med Chem. 1988 Nov;31(11):2136-45.Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.

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