Drug General Information
Drug ID	D0TG9Q
Former ID	DIB010467
Drug Name	MK-0812
Synonyms	C-6448; MK-812; CCR2 antagonist (rheumatoid arthritis/multiple sclerosis), Merck
Drug Type	Small molecular drug
Indication	Multiple scierosis [ICD9: 340; ICD10:G35]		Phase 2	[521746]
Company	Merck & Co Inc
Structure		Download 2D MOL 3D MOL
Formula	C24H34F3N3O3
Canonical SMILES	C1OCCC([C@@H]1OC)N[C@@H]1CC[C@](C1)(C(C)C)C(=O)N1CCc2c(<br />C1)cc(cn2)C(F)(F)F
CAS Number	CAS 1011472-76-6
PubChem Compound ID	71296092
Target and Pathway
Target(s)	C-C chemokine receptor type 2	Target Info	Antagonist	[530515]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
NetPath Pathway	TCR Signaling Pathway
	IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Leptin Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Reactome	Beta defensins
	Chemokine receptors bind chemokines
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Defensins
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 521746	ClinicalTrials.gov (NCT00239655) A Study to Assess the Effects of MK0812 on Disease Activity in Patients With Relapsing-Remitting Multiple Sclerosis as Measured by Magnetic Resonance Imaging (MRI). U.S. National Institutes of Health.
Ref 530515	Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist. J Immunol Methods. 2010 Jan 31;352(1-2):101-10.

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