Drug Information

Drug General Information
Drug ID
D0TJ2L
Former ID
DNC011726
Drug Name
RO-147437
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534008]
Structure
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2D MOL

3D MOL
Formula
C15H15N3O3
Canonical SMILES
CCOC(=O)C1=C2CN(C(=O)C3=CC=CC=C3N2C=N1)C
InChI
1S/C15H15N3O3/c1-3-21-15(20)13-12-8-17(2)14(19)10-6-4-5-7-11(10)18(12)9-16-13/h4-7,9H,3,8H2,1-2H3
InChIKey
HNGRWUCKESPKRC-UHFFFAOYSA-N
PubChem Compound ID
127597
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [534008]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
Serotonergic synapse
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 534008J Med Chem. 1993 Apr 16;36(8):1001-6.Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.
Ref 534008J Med Chem. 1993 Apr 16;36(8):1001-6.Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.

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