Drug Information

Drug General Information
Drug ID
D0TO6S
Former ID
DNC000324
Drug Name
Bisindolylmaleimide-I
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468250]
Structure
Download
2D MOL

3D MOL
Formula
C25H24N4O2
InChI
InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
InChIKey
QMGUOJYZJKLOLH-UHFFFAOYSA-N
CAS Number
CAS 133052-90-1
PubChem Compound ID
2396
PubChem Substance ID
13417, 584926, 833543, 854722, 854723, 3190764, 6394910, 7886205, 7980337, 8025846, 8032446, 8151603, 11113674, 11121765, 11122245, 11362914, 11365476, 11368038, 11371019, 11371020, 11373639, 11376200, 14781995, 26751859, 26751860, 26758304, 26758307, 29221561, 46393344, 46393744, 46507495, 47440042, 47810559, 47810560, 47959543, 48259034, 50064351, 50104559, 50167339, 53787665, 53800473, 53800958, 53800961, 57244620, 57321298, 84943909, 85084196, 85788293, 91590429, 92310116
Target and Pathway
Target(s) Protein kinase C, zeta type Target Info Inhibitor [535047]
KEGG Pathway Rap1 signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Hippo signaling pathway
Tight junction
Platelet activation
Insulin signaling pathway
Type II diabetes mellitus
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Angiogenesis
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
Pathway Interaction Database RhoA signaling pathway
Insulin Pathway
Noncanonical Wnt signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
CDC42 signaling events
Thromboxane A2 receptor signaling
IL1-mediated signaling events
Role of Calcineurin-dependent NFAT signaling in lymphocytes
CXCR4-mediated signaling events
IGF1 pathway
TNF receptor signaling pathway
IL2 signaling events mediated by PI3K
Ceramide signaling pathway
p75(NTR)-mediated signaling
amb2 Integrin signaling
ErbB1 downstream signaling
Neurotrophic factor-mediated Trk receptor signaling
Nephrin/Neph1 signaling in the kidney podocyte
Insulin-mediated glucose transport
Regulation of Ras family activation
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome GPVI-mediated activation cascade
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferation
WikiPathways Calcium Regulation in the Cardiac Cell
Insulin Signaling
EGF/EGFR Signaling Pathway
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
MAPK Signaling Pathway
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Signaling by TGF-beta Receptor Complex
Allograft Rejection
AGE/RAGE pathway
TNF alpha Signaling Pathway
Signaling Pathways in Glioblastoma
miRs in Muscle Cell Differentiation
IL-1 signaling pathway
GPVI-mediated activation cascade
Type II diabetes mellitus
References
Ref 468250(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5193).
Ref 535047Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines. J Neurooncol. 2000 Apr;47(2):109-15.

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