Drug Information

Drug General Information
Drug ID
D0TP8S
Former ID
DNC006971
Drug Name
3-(3-(carbamoyl)benzamido)-3-phenylpropanoic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528383]
Structure
Download
2D MOL

3D MOL
Formula
C26H25N3O4
Canonical SMILES
C1CNCC2=C1C=CC(=C2)NC(=O)C3=CC(=CC=C3)C(=O)NC(CC(=O)O)C<br />4=CC=CC=C4
InChI
1S/C26H25N3O4/c30-24(31)15-23(18-5-2-1-3-6-18)29-26(33)20-8-4-7-19(13-20)25(32)28-22-10-9-17-11-12-27-16-21(17)14-22/h1-10,13-14,23,27H,11-12,15-16H2,(H,28,32)(H,29,33)(H,30,31)
InChIKey
OCNALRIBAIFGLP-UHFFFAOYSA-N
PubChem Compound ID
44418281
Target and Pathway
Target(s) Integrin alpha-2 Target Info Inhibitor [528383]
mRNA of integrin beta 3 Target Info Inhibitor [528383]
KEGG Pathway Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Platelet activation
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Pathways in cancer
Proteoglycans in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathyhsa04015:Rap1 signaling pathway
Osteoclast differentiation
Thyroid hormone signaling pathway
MicroRNAs in cancer
Dilated cardiomyopathy
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling PathwayNetPath_22:Leptin Signaling Pathway
PANTHER Pathway Integrin signalling pathway
Pathway Interaction Database Beta1 integrin cell surface interactions
Integrin family cell surface interactions
Arf6 trafficking events
CXCR4-mediated signaling events
Plexin-D1 Signaling
Syndecan-2-mediated signaling events
VEGFR3 signaling in lymphatic endotheliumil4_2pathway:IL4-mediated signaling events
Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Osteopontin-mediated events
Nectin adhesion pathway
Arf6 signaling events
S1P1 pathway
Integrins in angiogenesis
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Signaling events mediated by VEGFR1 and VEGFR2
Ephrin B reverse signaling
Reactome Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
CHL1 interactions
Platelet Adhesion to exposed collagenR-HSA-114608:Platelet degranulation
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
MAP2K and MAPK activation
WikiPathways TGF beta Signaling Pathway
Focal Adhesion
Human Complement System
Extracellular matrix organization
Interleukin-11 Signaling Pathway
Arrhythmogenic Right Ventricular Cardiomyopathy
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
Platelet Adhesion to exposed collagen
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactionsWP727:Monoamine Transport
Osteoblast Signaling
Hematopoietic Stem Cell Differentiation
Syndecan interactions
Elastic fibre formation
Primary Focal Segmental Glomerulosclerosis FSGS
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
Cell surface interactions at the vascular wall
Serotonin Transporter Activity
Osteopontin Signaling
Osteoclast Signaling
References
Ref 528383Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. Epub 2006 Aug 21.Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists.
Ref 528383Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. Epub 2006 Aug 21.Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.