Drug General Information
Drug ID	D0TS8E
Former ID	DNCL003146
Drug Name	ADX71149
Indication	Psychiatric disorder [ICD9: 290-319; ICD10:F01-F99]		Discontinued in Phase 2	[548928]
Company	Addex Pharmaceuticals; Johnson & Johnson Pharmaceutical
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Metabotropic glutamate receptor 2	Target Info	Modulator	[551580]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
	Cocaine addiction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group II pathway
Reactome	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548928	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030424)
Ref 551580	MGlu2 receptor-mediated modulation of conditioned avoidance behavior in rats. European journal of pharmacology. 01/2014; 727(1).

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