Drug General Information
Drug ID
D0TU5W
Former ID
DNC003543
Drug Name
4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534802]
Structure
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2D MOL

3D MOL

Formula
C19H20ClN3
Canonical SMILES
C1CN(CCN1CC2=CC=CC=C2)C3=C(C=CC4=C3C=CN4)Cl
InChI
1S/C19H20ClN3/c20-17-6-7-18-16(8-9-21-18)19(17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
InChIKey
IRFLVVGRMBDQSJ-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Inhibitor [534802]
D(4) dopamine receptor Target Info Inhibitor [534802]
D(2) dopamine receptor Target Info Inhibitor [534802]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
References
Ref 534802Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80.New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template.
Ref 534802Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80.New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template.

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