Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0TY8X
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| Former ID |
DNC005902
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| Drug Name |
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [529948] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C10H11N5O2S
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| Canonical SMILES |
C1=CC(=CC=C1NC2=NC(=NC=C2)N)S(=O)(=O)N
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| InChI |
1S/C10H11N5O2S/c11-10-13-6-5-9(15-10)14-7-1-3-8(4-2-7)18(12,16)17/h1-6H,(H2,12,16,17)(H3,11,13,14,15)
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| InChIKey |
QOAXQANKSMHFKJ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Carbonic anhydrase | Target Info | Inhibitor | [529948] | |
| Carbonic anhydrase I | Target Info | Inhibitor | [537461] | ||
| Carbonic anhydrase IX | Target Info | Inhibitor | [529948] | ||
| Carbonic anhydrase VI | Target Info | Inhibitor | [529948] | ||
| Carbonic anhydrase II | Target Info | Inhibitor | [530466] | ||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| EGFR1 Signaling Pathway | |||||
| Pathway Interaction Database | C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
| Erythrocytes take up oxygen and release carbon dioxide | |||||
| Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor | |||||
| Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
| Reversible hydration of carbon dioxide | |||||
| WikiPathways | Reversible Hydration of Carbon Dioxide | ||||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway | |||||
| Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | |||||
| References | |||||
| Ref 529948 | J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. | ||||
| Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
| Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. | ||||
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