Drug Information

Drug General Information
Drug ID
D0U0KW
Former ID
DAP000070
Drug Name
Ramelteon
Synonyms
Rozerem; Ramelteon [USAN]; Rozerem (TN); TAK-375; Ramelteon (JAN/USAN/INN); Rozerem, TAK-375, Ramelteon; N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide; N-{2-[(8s)-1,6,7,8-tetrahydro-2h-indeno[5,4-b]fur-8-yl]ethyl}propanamid; (-)-N-(2-(((8S)-1,6,7,8-Tetrahydro-2H-indeno(5,4-b)furan-8-yl)ethyl)propanamide; (S)-N-(2-(1,6,7,8-tetrahydro-2H-indeno-(5,4)furan-8-yl)ethyl)propionamide
Drug Type
Small molecular drug
Indication Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] Approved [536647], [538833]
Circadian rhythm sleep disorder [ICD9: 327.3, 780.55; ICD10:G47.2] Terminated [536647], [538833]
Therapeutic Class
Hypnotics and Sedatives
Company
Takeda
Structure
Download
2D MOL

3D MOL
Formula
C16H21NO2
InChI
InChI=1S/C16H21NO2/c1-2-15(18)17-9-7-12-4-3-11-5-6-14-13(16(11)12)8-10-19-14/h5-6,12H,2-4,7-10H2,1H3,(H,17,18)/t12-/m0/s1
InChIKey
YLXDSYKOBKBWJQ-LBPRGKRZSA-N
CAS Number
CAS 196597-26-9
PubChem Compound ID
208902
PubChem Substance ID
9368722, 12015157, 14823708, 14847999, 17396858, 26612945, 30413545, 46505923, 47810466, 50070191, 50070903, 50810551, 57399556, 71825382, 81065549, 85789647, 90342558, 92124722, 92307942, 92721412, 99437057, 103370203, 103838767, 104011788, 113442055, 117539034, 124757124, 124772078, 125163928, 126592922, 126627642, 126651547, 126667057, 129814520, 134337398, 135184679, 135651228, 136949090, 137005126, 142796849, 143496454, 152035160, 152164855, 152237728, 152258949, 160647794, 160964318, 162011666, 162184404, 163122411
SuperDrug ATC ID
N05CH02
Target and Pathway
Target(s) Melatonin receptor Target Info Modulator [529337], [532551]
Melatonin receptor type 1B Target Info Modulator [529337], [532551]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainmenthsa04080:Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 536647Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62.
Ref 538833(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1356).
Ref 529337Ramelteon: a melatonin receptor agonist for the treatment of insomnia. J Postgrad Med. 2008 Jan-Mar;54(1):45-8.
Ref 532551MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential. J Med Chem. 2014 Apr 24;57(8):3161-85.

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