Drug Information

Drug General Information
Drug ID
D0U1IR
Former ID
DIB014488
Drug Name
AP-5346
Synonyms
ProLindac; AP-5286; DACH polymer platinate, Access; DACH-Pt; DACH-Pt prodrug
Indication Head and neck cancer [ICD9: 140-149, 140-229; ICD10:C07-C14, C32-C33] Discontinued in Phase 2 [547589]
Company
Access Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Canonical SMILES
[Na+].C1CCC[C@H]([C@@H]1N)N.[Pt+2].[Pt+2].C1CCC[C@H]([C<br />@@H]1N)N.[Pt+2].C1CCC[C@H]([C@@H]1N)N.[Na+].C(C(=O)NCC(<br />C)O)(C)(*)CC(CC(CC(C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)[N-<br />]C(C(=O)[O-])C(=O)[O-])(CC(*)(C(=O)NCC(C)O)C)C)(C(=O)NC<br />C(C)O)C)(C)C(=O)NCC(=O)NCC(=O)[N-]/C=C(\[N-]C(C(=O)[O-]<br/>)C(=O)[O-])/[O-]
Target and Pathway
Target(s) Human DNA Target Info Inhibitor [528127]
References
Ref 547589Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017581)
Ref 528127Preclinical efficacy and pharmacokinetics of AP5346, a novel diaminocyclohexane-platinum tumor-targeting drug delivery system. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2248-54.

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