Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U2UJ
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| Former ID |
DNC003855
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| Drug Name |
1-(2-hydroxy-4-nitrophenyl)-3-phenylurea
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| Synonyms |
1-(2-Hydroxy-4-nitro-phenyl)-3-phenyl-urea
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [528628] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C13H11N3O4
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| Canonical SMILES |
C1=CC=C(C=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O
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| InChI |
1S/C13H11N3O4/c17-12-8-10(16(19)20)6-7-11(12)15-13(18)14-9-4-2-1-3-5-9/h1-8,17H,(H2,14,15,18)
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| InChIKey |
SAUHQYBXEGARCC-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | High affinity interleukin-8 receptor B | Target Info | Inhibitor | [528628] | |
| High affinity interleukin-8 receptor A | Target Info | Inhibitor | [526980] | ||
| NetPath Pathway | TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway | ||||
| Pathway Interaction Database | IL8- and CXCR2-mediated signaling eventsil8cxcr1_pathway:IL8- and CXCR1-mediated signaling events | ||||
| References | |||||
| Ref 526980 | J Med Chem. 2004 Mar 11;47(6):1319-21.Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. | ||||
| Ref 528628 | Bioorg Med Chem Lett. 2007 Mar 15;17(6):1713-7. Epub 2006 Dec 23.Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor. | ||||
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