Drug Information

Drug General Information
Drug ID
D0U5CS
Former ID
DCL000158
Drug Name
LY354740
Synonyms
Eglumegad; Eglumetad; Eglumegad [INN]; Eglumegad [USAN]; Eglumegad hydrate; Eglumetad hydrate; LY 314582; LY 354740; LY 366563; LY314582; LY366563; Eglumegad (USAN); LY-314582; LY-354740; LY-354740 monohydrate; LY-366563; Eglumetad (INN/USAN); (1R,4S,5S,6S)-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylic acid; (1R,4S,5S,6S)-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylic acid hydrate; (1S,2S,5R,6S)-2-Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic acid; (1S,2S,5R,6S)-2-Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic acid monohydrate; (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; 2-Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic acid; 4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 2 [538869], [546477]
Company
Eli Lilly
Structure
Download
2D MOL

3D MOL
Formula
C8H11NO4
InChI
InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
InChIKey
VTAARTQTOOYTES-RGDLXGNYSA-N
CAS Number
CAS 176199-48-7
PubChem Compound ID
213056
PubChem Substance ID
7979829, 9371121, 14748421, 15171407, 30417292, 49893662, 57399664, 76123878, 96025591, 99374044, 103066678, 103078431, 103167812, 103952580, 113453194, 117518357, 126681491, 129522756, 134222157, 134338837, 134342627, 135188014, 135650554, 135651173, 137008428, 141864460, 143494992, 152039494, 152165111, 152238648, 162221554, 163304092, 163346685, 170485584, 198977294, 202548619, 204373912, 223661924, 223886305, 225144924, 226393133, 226797883, 249727659, 252213797
Target and Pathway
Target(s) Metabotropic glutamate receptor3 Target Info Agonist [536959], [537037], [537272]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 538869(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1393).
Ref 546477Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008428)
Ref 536959Modulation of group II metabotropic glutamate receptor (mGlu2) elicits common changes in rat and mice sleep-wake architecture. Eur J Pharmacol. 2009 Jan 28;603(1-3):62-72. Epub 2008 Nov 17.
Ref 537037Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition. Behav Pharmacol. 2009 Feb;20(1):56-66.
Ref 537272Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist (3)H-HYDIA. ChemMedChem. 2009 Jul;4(7):1086-94.

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