TTD | Drug: D0U5HS

Drug General Information
Drug ID	D0U5HS
Former ID	DIB020169
Drug Name	L748328
Synonyms	L-748328; L-748,328
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540401]
Structure		Download 2D MOL
Formula	C23H27N3O6S2
InChI	InChI=1S/C23H27N3O6S2/c24-33(28,29)23-8-4-5-21(15-23)32-17-20(27)16-25-14-13-18-9-11-19(12-10-18)26-34(30,31)22-6-2-1-3-7-22/h1-12,15,20,25-27H,13-14,16-17H2,(H2,24,28,29)/t20-/m0/s1
InChIKey	CVPJSQZQNBKALR-FQEVSTJZSA-N
PubChem Compound ID	10323892
PubChem Substance ID	15333403, 22693247, 41389709, 53801070, 78541705, 124961482, 228173978
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Antagonist	[525542]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
Reactome	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540401	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3463).
Ref 525542	Potent and selective human beta(3)-adrenergic receptor antagonists. J Pharmacol Exp Ther. 1999 Aug;290(2):649-55.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Drug Information