Drug Information

Drug General Information
Drug ID
D0U5LL
Former ID
DIB019060
Drug Name
cannabinol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542422]
Structure
Download
2D MOL
Formula
C21H26O2
InChI
InChI=1S/C21H26O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h9-13,22H,5-8H2,1-4H3
InChIKey
VBGLYOIFKLUMQG-UHFFFAOYSA-N
PubChem Compound ID
2543
PubChem Substance ID
9782, 423125, 841254, 4688526, 8150127, 8151685, 10525129, 11336147, 11361386, 11462358, 14752180, 24892874, 24892909, 29221705, 47810837, 49962236, 50113074, 50561854, 57309734, 57321366, 57654033, 57654037, 74382082, 85208997, 99302060, 103274782, 103856333, 103956704, 104300896, 129450190, 134977205, 135650052, 137003699, 142472555, 144207035, 162220714, 164837692, 176262245, 179148437, 198959880, 223439214, 224904146, 226492602, 241090056, 241376281, 250114444, 252157042
Target and Pathway
Target(s) TRPV2 Target Info Activator [529533]
Cannabinoid receptor 1 Target Info Agonist [534216]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 542422(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 740).
Ref 529533TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci. 2008 Jun 11;28(24):6231-8.
Ref 534216Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther. 1996 Sep;278(3):989-99.

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