Drug Information

Drug General Information
Drug ID
D0U5VZ
Former ID
DAP001061
Drug Name
Bepotastine
Synonyms
Betotastine; Tau 284; TAU-284DS; Talion (TN); (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid; 4-((4-Chlorophenyl)-2-pyridinylmethoxy)-1-piperidinebutanoic acid; 4-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid
Drug Type
Small molecular drug
Indication Allergic rhinitis; Urticaria; Pruritus [ICD9: 477, 708; ICD10:J30, L50] Approved [536119], [542491]
Therapeutic Class
Antiallergic Agents
Company
Tanabe Seiyaku Co
Structure
Download
2D MOL

3D MOL
Formula
C21H25ClN2O3
InChI
InChI=1S/C21H25ClN2O3/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26)/t21-/m0/s1
InChIKey
YWGDOWXRIALTES-NRFANRHFSA-N
CAS Number
CAS 190786-44-8
PubChem Compound ID
164522
PubChem Substance ID
14829848, 14902947, 23920714, 46238701, 75020756, 103813930, 113454187, 117462449, 119526563, 123087811, 124490445, 127327794, 127327795, 129857231, 135086471, 135374324, 137005445, 142507415, 143495901, 152053402, 152237662, 160646105, 162189322, 163300204, 164829665, 174528119, 175266558, 175438136, 176251674, 179150117, 187051769, 210276615, 210279871, 211534992, 223532849, 223756030, 226416530, 249855756, 250194992, 251916770, 251918009, 252077531, 252430565, 252434265
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [536767]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536119Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.
Ref 542491(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7466).
Ref 536767Mast cells play a critical role in the pathogenesis of viral myocarditis. Circulation. 2008 Jul 22;118(4):363-72. Epub 2008 Jul 7.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.