Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U6ML
|
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| Former ID |
DNC000440
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| Drug Name |
CKD602
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| Drug Type |
Small molecular drug
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Phase 2 | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C25H28ClN3O4
|
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| Canonical SMILES |
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC<br />(C)C)O.Cl
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| InChI |
1S/C25H27N3O4.ClH/c1-4-25(31)19-11-21-22-17(12-28(21)23(29)18(19)13-32-24(25)30)15(9-10-26-14(2)3)16-7-5-6-8-20(16)27-22;/h5-8,11,14,26,31H,4,9-10,12-13H2,1-3H3;1H/t25-;/m0./s1
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| InChIKey |
SJKBXKKZBKCHET-UQIIZPHYSA-N
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| CAS Number |
CAS 256411-32-2
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | DNA topoisomerase I | Target Info | Inhibitor | [2] | |
| WikiPathways | Integrated Pancreatic Cancer Pathway | ||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00430144) Belotecan (CKD-602) in Recurrent or Progressive Carcinoma of Uterine Cervix. U.S. National Institutes of Health. | ||||
| REF 2 | Antitumor activity of 7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin, CKD602, as a potent DNA topoisomerase I inhibitor. Arch Pharm Res. 1998 Oct;21(5):581-90. | ||||
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