Drug Information

Drug General Information
Drug ID
D0U7FE
Former ID
DNC006581
Drug Name
N-(4-tert-butylthiazol-2-yl)quinolin-5-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528047]
Structure
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2D MOL

3D MOL
Formula
C16H17N3S
Canonical SMILES
CC(C)(C)C1=CSC(=N1)NC2=CC=CC3=C2C=CC=N3
InChI
1S/C16H17N3S/c1-16(2,3)14-10-20-15(19-14)18-13-8-4-7-12-11(13)6-5-9-17-12/h4-10H,1-3H3,(H,18,19)
InChIKey
RGBQNFYMCAUMHK-UHFFFAOYSA-N
PubChem Compound ID
9900444
Target and Pathway
Target(s) C-Cchemokine receptor type 4 Target Info Inhibitor [528047]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesis
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528047Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. Epub 2006 Feb 23.Optimization of 2-aminothiazole derivatives as CCR4 antagonists.
Ref 528047Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. Epub 2006 Feb 23.Optimization of 2-aminothiazole derivatives as CCR4 antagonists.

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