Drug Information

Drug General Information
Drug ID
D0U7PM
Former ID
DIB011998
Drug Name
OPL-CCL2-LPM
Synonyms
CCR2 targeting agent (arthritis/nephritis/cardiovascular/pulmonaryl/CNS); Leukocyte population modulator (arthritis/nephritis/cardiovascular/pulmonary/CNS), Osprey
Indication Arthritis [ICD9: 710-719; ICD10:M00-M25] Phase 1 [548903]
Company
Osprey Pharmaceuticals Ltd
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Modulator [544075]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 548903Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030092)
Ref 544075Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis. Clin Exp Immunol. 2009 February; 155(2): 295-303.

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