Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U8AS
|
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| Former ID |
DNCL002514
|
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| Drug Name |
Telapristone
|
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| Drug Type |
Small molecular drug
|
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| Indication | Endometriosis [ICD9: 617; ICD10:N80] | Phase 2 | [1] | ||
| Company |
Repros Therapeutics
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C31H39NO5
|
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| Canonical SMILES |
CC(=O)OC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)<br />N(C)C)C)C(=O)COC
|
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| InChI |
1S/C31H39NO5/c1-19(33)37-31(28(35)18-36-5)15-14-27-25-12-8-21-16-23(34)11-13-24(21)29(25)26(17-30(27,31)2)20-6-9-22(10-7-20)32(3)4/h6-7,9-10,16,25-27H,8,11-15,17-18H2,1-5H3/t25-,26+,27-,30-,31-/m0/s1
|
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| InChIKey |
JVBGZFRPTRKSBB-MJBQOYBXSA-N
|
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| CAS Number |
CAS 198414-31-2
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Progesterone receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Oocyte meiosis | ||||
| Progesterone-mediated oocyte maturation | |||||
| Pathway Interaction Database | Cellular roles of Anthrax toxin | ||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Nuclear Receptor transcription pathway | |||||
| WikiPathways | Ovarian Infertility Genes | ||||
| Signaling by ERBB4 | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014404) | ||||
| REF 2 | In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol. 2004 Mar;88(3):277-88. | ||||
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