Drug Information

Drug General Information
Drug ID
D0U8HD
Former ID
DIB018546
Drug Name
2-chloroadenosine-5-triphosphate
Synonyms
2-chloro-ATP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539068]
Structure
Download
2D MOL
Formula
C10H15ClN5O13P3
InChI
InChI=1S/C10H15ClN5O13P3/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21)/t3-,5-,6-,9-/m1/s1
InChIKey
RNGCVFCOKZEZFL-UUOKFMHZSA-N
PubChem Compound ID
162565
PubChem Substance ID
10254913, 14812373, 14934734, 46237203, 57349922, 75693773, 103117285, 103117286, 113449758, 117627119, 129153730, 135118519, 135649697, 163110300, 164141674, 164151260, 184531455, 228181983
Target and Pathway
Target(s) P2Y purinoceptor 1 Target Info Antagonist [534603]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome G alpha (q) signalling events
P2Y receptors
ADP signalling through P2Y purinoceptor 1
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539068(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1716).
Ref 534603ATP derivatives are antagonists of the P2Y1 receptor: similarities to the platelet ADP receptor. Mol Pharmacol. 1998 Apr;53(4):727-33.

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