Drug Information

Drug General Information
Drug ID
D0U8QB
Former ID
DIB001151
Drug Name
JTT-851
Synonyms
GPCR 40 agonist (type 2 diabetes) Japan Tobacco
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 2 [524085]
Company
Akros pharma
Target and Pathway
Target(s) GPR40 Target Info Agonist [544438]
KEGG Pathway Insulin secretion
Reactome G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
WikiPathways GPCRs, Class A Rhodopsin-like
Incretin Synthesis, Secretion, and Inactivation
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 524085ClinicalTrials.gov (NCT01699737) Safety and Efficacy Study of JTT-851 in Patients With Type 2 Diabetes Mellitus. U.S. National Institutes of Health.
Ref 544438Treatment of Type 2 Diabetes by Free Fatty Acid Receptor Agonists. Front Endocrinol (Lausanne) 2014; 5: 137.

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