Drug Information

Drug General Information
Drug ID
D0UD7H
Former ID
DIB018450
Drug Name
1,6-hexamethylene diisocyanate
Synonyms
HMDI; HDI
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541442]
Structure
Download
2D MOL
Formula
C8H12N2O2
InChI
InChI=1S/C8H12N2O2/c11-7-9-5-3-1-2-4-6-10-8-12/h1-6H2
InChIKey
RRAMGCGOFNQTLD-UHFFFAOYSA-N
PubChem Compound ID
13192
PubChem Substance ID
76570, 588353, 3132927, 4920802, 8159928, 10532153, 10536552, 14916253, 24866192, 24866194, 24874557, 24874558, 24893386, 26757592, 29281357, 30337876, 48417714, 48421569, 49976107, 53787128, 56368636, 57244219, 57328018, 57651377, 78464611, 85247392, 87246469, 87570744, 88824472, 104331113, 104668778, 117587517, 118316851, 124892891, 124892892, 125358134, 126545901, 126674730, 127327879, 127327880, 127327881, 127327882, 127327883, 127327884, 127327885, 129169394, 131327228, 134977770, 135594617, 137008811
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily A member 1 Target Info Activator [529822]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 541442(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6291).
Ref 529822Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. 2009 Apr;23(4):1102-14.

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