TTD | Drug: D0UG1U

Drug General Information
Drug ID	D0UG1U
Former ID	DIB021144
Drug Name	UR-PG55B
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538715]
Structure		Download 2D MOL
Formula	C22H23F2N5O
InChI	InChI=1S/C22H23F2N5O/c23-17-7-3-15(4-8-17)20(16-5-9-18(24)10-6-16)12-21(30)29-22(25)27-11-1-2-19-13-26-14-28-19/h3-10,13-14,20H,1-2,11-12H2,(H,26,28)(H3,25,27,29,30)
InChIKey	BRPONMOKDIJLJF-UHFFFAOYSA-N
PubChem Compound ID	25150704
PubChem Substance ID	103649234, 135651302, 163362200
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Agonist	[527955]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
Reactome	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538715	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1202).
Ref 527955	Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. Epub 2006 Jan 4.

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Drug Information