Drug Information

Drug General Information
Drug ID
D0UI3L
Former ID
DIB019741
Drug Name
dihydroergocryptine
Synonyms
dihydroergokryptine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539862]
Structure
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2D MOL

3D MOL
Formula
C32H43N5O5
InChI
InChI=1S/C32H43N5O5/c1-17(2)12-25-29(39)36-11-7-10-26(36)32(41)37(25)30(40)31(42-32,18(3)4)34-28(38)20-13-22-21-8-6-9-23-27(21)19(15-33-23)14-24(22)35(5)16-20/h6,8-9,15,17-18,20,22,24-26,33,41H,7,10-14,16H2,1-5H3,(H,34,38)
InChIKey
PBUNVLRHZGSROC-UHFFFAOYSA-N
PubChem Compound ID
522609
PubChem Substance ID
24578927, 39350805, 51746469, 85209886, 92955084, 109769090, 117855430, 118393084, 124599087, 124894386, 126433160, 131342027, 131818735, 135650181, 179293613, 249909987
Target and Pathway
Target(s) 5-hydroxytryptamine 7 receptor Target Info Antagonist [534022]
5-hydroxytryptamine 2B receptor Target Info Agonist [532279]
KEGG Pathway Ras signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
References
Ref 539862(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 282).
Ref 532279Structural features for functional selectivity at serotonin receptors. Science. 2013 May 3;340(6132):615-9.
Ref 534022Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol. 1993 Aug;44(2):229-36.

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