Drug Information

Drug General Information
Drug ID
D0UI3T
Former ID
DNCL002721
Drug Name
Elagolix
Drug Type
Small molecular drug
Indication Uterine leiomyoma [ICD9: 218.9; ICD10:D25] Phase 3 [523945], [543088]
Company
Abbott Laboratories Abbott; Neurocrine Biosciences
Structure
Download
2D MOL

3D MOL
Formula
C32H30F5N3O5
InChI
InChI=1S/C32H30F5N3O5/c1-19-28(21-11-6-14-26(45-2)29(21)34)30(43)40(18-25(20-9-4-3-5-10-20)38-16-8-15-27(41)42)31(44)39(19)17-22-23(32(35,36)37)12-7-13-24(22)33/h3-7,9-14,25,38H,8,15-18H2,1-2H3,(H,41,42)/t25-/m0/s1
InChIKey
HEAUOKZIVMZVQL-VWLOTQADSA-N
PubChem Compound ID
11250647
PubChem Substance ID
16335306, 23427966, 42330194, 78324891, 96026015, 126679932, 135253513, 137832933, 160682500, 180371722, 186000973, 198990581, 202535683, 223682681, 227832329, 247942522, 252166574
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Antagonist [533106]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 523945ClinicalTrials.gov (NCT01620528) A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain. U.S. National Institutes of Health.
Ref 543088(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8362).
Ref 533106Elagolix, a novel, orally bioavailable GnRH antagonist under investigation for the treatment of endometriosis-related pain. Womens Health (Lond Engl). 2015 Jan;11(1):19-28.

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