Drug Information

Drug General Information
Drug ID
D0UQ6J
Former ID
DNC011747
Drug Name
RO-194603
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467636]
Structure
Download
2D MOL

3D MOL
Formula
C15H17N3O3S
InChI
InChI=1S/C15H17N3O3S/c1-15(2,3)21-14(20)11-10-7-17(4)13(19)12-9(5-6-22-12)18(10)8-16-11/h5-6,8H,7H2,1-4H3
InChIKey
ZIGMMUKDYCABPW-UHFFFAOYSA-N
PubChem Compound ID
127382
PubChem Substance ID
586305, 7980532, 10241758, 11114258, 29306674, 47285939, 47880172, 78645845, 103164534, 103850244, 103942961, 104365686, 117550484, 129906605, 134348952, 135082773, 135698298, 138742161, 162023137, 163113200, 177748541, 178101114, 179293778, 184538636, 223442228, 223454622, 224896397, 228573030, 241170337, 241375732, 249617464, 251962114, 252156243, 252341850
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor Target Info Inhibitor [534008]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 467636(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4297).
Ref 534008J Med Chem. 1993 Apr 16;36(8):1001-6.Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.

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