Drug Information

Drug General Information
Drug ID
D0UT3F
Former ID
DIB012617
Drug Name
Nolpitantium besilate
Synonyms
SR-140333; SR-140333B
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [539335], [545622]
Company
Sanofi-Synthelabo; Sanofi-aventis
Structure
Download
2D MOL

3D MOL
Formula
C37H45Cl2N2O2+
InChI
InChI=1S/C37H45Cl2N2O2/c1-28(2)43-32-11-6-8-29(24-32)25-35(42)40-19-7-14-37(27-40,31-12-13-33(38)34(39)26-31)18-23-41-20-15-36(16-21-41,17-22-41)30-9-4-3-5-10-30/h3-6,8-13,24,26,28H,7,14-23,25,27H2,1-2H3/q+1/t36?,37-,41?/m1/s1
InChIKey
RPDFDSQFBCJTDY-GAQXSTBRSA-N
PubChem Compound ID
108167
PubChem Substance ID
14765314, 14936508, 44437049, 49873469, 80040589, 103964404, 104380663, 129161570, 135651073, 163641729, 179149990, 198942482, 228278101, 242090950
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [533608]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539335(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2107).
Ref 545622Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003930)
Ref 533608SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line. J Neurochem. 1994 Apr;62(4):1399-407.

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