Drug Information

Drug General Information
Drug ID
D0UV4H
Former ID
DIB011199
Drug Name
GSK-706769
Synonyms
GSK-163929; GSK-929; CCR5 antagonist (HIV), GSK; CCR5 antagonist (HIV), ViiV; CCR5 chemokine antagonists (HIV-1 infection),GlaxoSmithKline
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 2 [522788]
Company
GlaxoSmithKline plc
Structure
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2D MOL

3D MOL
Canonical SMILES
CC(C)(C(=O)N1CCC(CCN2CCC(CC2)N(C(=O)NCc2ccc(cc2)C#N)c2c<br />c(ccc2)F)(c2cccc(c2)F)CC1)O
Target and Pathway
Target(s) C-C chemokinereceptor type 5 Target Info Antagonist [530181]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Toxoplasmosis
Viral carcinogenesis
NetPath Pathway TSLP Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Reactome Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
HIV Life Cycle
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 522788ClinicalTrials.gov (NCT00979771) A Study to Investigate the Ability of GSK706769 to Maintain Clinical Remission After Withdrawal of Enbrel in Rheumatoid Arthritis Patients. U.S. National Institutes of Health.
Ref 530181Tapping into combination pills for HIV. Nat Rev Drug Discov. 2009 Jun;8(6):439-40.

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