Drug General Information
Drug ID	D0V0CJ
Former ID	DNCL002647
Drug Name	CO-101
Drug Type	Small molecular drug
Indication	Metastatic pancreatic [ICD10:C25.9]		Phase 2	[523237]
Company	Clovis Oncology
Structure		Download 2D MOL 3D MOL
Formula	C11H13NO3
Canonical SMILES	CN(C)C(=O)C1=CC=CC=C1C(=O)OC
InChI	1S/C11H13NO3/c1-12(2)10(13)8-6-4-5-7-9(8)11(14)15-3/h4-7H,1-3H3
InChIKey	HJPZFXYWMRWNHV-UHFFFAOYSA-N
PubChem Compound ID	213517
PubChem Substance ID	608203, 9371363, 30417668, 50010075, 80532239, 103828635, 113454318, 117552723, 135187053, 162826520
Target and Pathway
Target(s)	Human DNA	Target Info	Inhibitor	[528281]
	Ribonucleoside-diphosphatereductase subunit M2	Target Info	Inhibitor	[528281]
BioCyc Pathway	Pyrimidine deoxyribonucleotides biosynthesis from CTP
	Pyrimidine deoxyribonucleotides de novo biosynthesis
	Guanosine nucleotides de novo biosynthesis
	Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
	Superpathway of purine nucleotide salvage
	Purine nucleotides de novo biosynthesis
	Adenosine deoxyribonucleotides de novo biosynthesis
	Guanosine deoxyribonucleotides de novo biosynthesis
KEGG Pathway	Purine metabolism
	Pyrimidine metabolism
	Glutathione metabolism
	Metabolic pathways
	p53 signaling pathway
NetPath Pathway	EGFR1 Signaling Pathway
PANTHER Pathway	p53 pathway
	De novo purine biosynthesis
	De novo pyrimidine deoxyribonucleotide biosynthesis
Pathway Interaction Database	E2F transcription factor network
PathWhiz Pathway	Purine Metabolism
	Pyrimidine Metabolism
Reactome	E2F mediated regulation of DNA replication
	G1/S-Specific Transcription
WikiPathways	Nucleotide Metabolism
	Retinoblastoma (RB) in Cancer
	Metabolism of nucleotides
	Fluoropyrimidine Activity
References
Ref 523237	ClinicalTrials.gov (NCT01233375) Study to Evaluate Efficacy of CO-1.01 as Second Line Therapy for Gemcitabine-Refractory Stage IV Pancreatic Adenocarcinoma. U.S. National Institutes of Health.
Ref 528281	Cellular pharmacology of gemcitabine. Ann Oncol. 2006 May;17 Suppl 5:v7-12.

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