Drug General Information
Drug ID	D0V0YP
Former ID	DNC006466
Drug Name	3-(thiophen-3-yl)-1H-indol-6-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528040]
Structure		Download 2D MOL 3D MOL
Formula	C12H10N2S
Canonical SMILES	C1=CC2=C(C=C1N)NC=C2C3=CSC=C3
InChI	1S/C12H10N2S/c13-9-1-2-10-11(6-14-12(10)5-9)8-3-4-15-7-8/h1-7,14H,13H2
InChIKey	QEKXSCXVUJXAFF-UHFFFAOYSA-N
PubChem Compound ID	44410875
Target and Pathway
Target(s)	Inosine-5'-monophosphate dehydrogenase 2	Target Info	Inhibitor	[528040]
BioCyc Pathway	Purine nucleotides degradation
	Urate biosynthesis/inosine 5'-phosphate degradation
	Guanosine nucleotides de novo biosynthesis
	Superpathway of purine nucleotide salvage
	Purine nucleotides de novo biosynthesis
	Guanosine ribonucleotides de novo biosynthesis
KEGG Pathway	Purine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways
PANTHER Pathway	De novo purine biosynthesis
Reactome	Purine ribonucleoside monophosphate biosynthesis
References
Ref 528040	Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. Epub 2006 Feb 17.Low molecular weight indole fragments as IMPDH inhibitors.
Ref 528040	Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. Epub 2006 Feb 17.Low molecular weight indole fragments as IMPDH inhibitors.

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