Drug Information

Drug General Information
Drug ID
D0V4FK
Former ID
DNC001344
Drug Name
SM 11044
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [526162]
Structure
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2D MOL

3D MOL
Formula
C22H28BrFN2O4
Canonical SMILES
C1CCN(C1)C(=O)C(C(C2=CC(=C(C=C2)O)O)O)NCCCC3=CC=C(C=C3)<br />F.Br
InChI
1S/C22H27FN2O4.BrH/c23-17-8-5-15(6-9-17)4-3-11-24-20(22(29)25-12-1-2-13-25)21(28)16-7-10-18(26)19(27)14-16;/h5-10,14,20-21,24,26-28H,1-4,11-13H2;1H/t20-,21+;/m0./s1
InChIKey
VGHBGPUSJITFJL-JUDYQFGCSA-N
CAS Number
CAS 142784-65-4
PubChem Compound ID
132507
PubChem Substance ID
14785756, 29310640, 79287159, 104377617, 134340539, 135088835
SuperDrug ATC ID
P01CX03
SuperDrug CAS ID
cas=070052129
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [537970]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 526162The iodocyanopindolol and SM-11044 binding protein belongs to the TM9SF multispanning membrane protein superfamily. Gene. 2001 Aug 8;273(2):227-37.
Ref 537970Effects of several putative beta 3-adrenoceptor agonists on lipolysis in human omental adipocytes. Int J Obes Relat Metab Disord. 1996 May;20(5):428-34.

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