Drug General Information
Drug ID	D0V4NY
Former ID	DIB012136
Drug Name	Cathepsin C inhibitors
Synonyms	Cathepsin C inhibitors (inflammation); Cathepsin C inhibitors (inflammation), Merck & Co
Indication	Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25]		Investigative	[528870]
Company	Merck & Co Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1([C@H]2C[C@]2(NC(=O)[C@H](Cc2sccc2)N)C#N)ccccc1
Target and Pathway
Target(s)	Dipeptidyl-peptidase I	Target Info	Inhibitor	[543599]
KEGG Pathway	Lysosome
NetPath Pathway	IL2 Signaling Pathway
	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
Reactome	COPII (Coat Protein 2) Mediated Vesicle Transport
	MHC class II antigen presentation
	Cargo concentration in the ER
WikiPathways	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBase
References
Ref 528870	J Biol Chem. 2007 Jul 20;282(29):20836-46. Epub 2007 May 29.Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.
Ref 543599	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2344).

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