Drug Information

Drug General Information
Drug ID
D0V4PH
Former ID
DIB015233
Drug Name
Tolerimab (anti-CD80/CD86)
Synonyms
Transplant rejection therapy, Innogenetics; MAbs (organ transplant), Innogenetics; Monoclonal antibodies (organ transplant), Innogenetics; ToleriMab (anti-B7.1/B7.2)
Drug Type
Antibody
Indication Transplant rejection [ICD9: 279.5, 996; ICD10:D89.8, T86] Terminated [546944]
Company
Innogenetics NV
Target and Pathway
Target(s) T-lymphocyte activation antigen CD86 Target Info [551916]
T-lymphocyte activation antigen CD80 Target Info [551916]
KEGG Pathway Cell adhesion molecules (CAMs)
Toll-like receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Transcriptional misregulation in cancer
Autoimmune thyroid disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditishsa04514:Cell adhesion molecules (CAMs)
Viral myocarditis
NetPath Pathway TCR Signaling Pathway
IL3 Signaling Pathway
IL4 Signaling Pathway
RANKL Signaling PathwayNetPath_22:Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway T cell activationP00053:T cell activation
Pathway Interaction Database TCR signaling in na&#xef
TCR signaling in na&#xef
IL12 signaling mediated by STAT4tcr_pathway:TCR signaling in na&#xef
IL12 signaling mediated by STAT4
Reactome PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signalingR-HSA-1257604:PIP3 activates AKT signaling
CTLA4 inhibitory signaling
WikiPathways Toll-like receptor signaling pathway
Inflammatory Response Pathway
IL-3 Signaling Pathway
PIP3 activates AKT signaling
Allograft Rejection
Costimulation by the CD28 family
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Primary Focal Segmental Glomerulosclerosis FSGS
Regulation of toll-like receptor signaling pathway
References
Ref 546944Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011393)
Ref 551916US patent application no. 2004,0171,123, Albumin fusion proteins.

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