Drug General Information
Drug ID	D0V5FQ
Former ID	DIB005116
Drug Name	Axitirome
Synonyms	CGP-26214; CGS-25845; CGS-26214
Drug Type	Small molecular drug
Indication	Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78]		Phase 1	[544305]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Formula	C25H24FNO6
Canonical SMILES	c1(C(c2ccc(cc2)F)O)c(ccc(Oc2c(cc(NC(=O)C(=O)OCC)cc2C)C)<br />c1)O
CAS Number	CAS 156740-57-7
PubChem Compound ID	166559
Target and Pathway
Target(s)	Thyroid hormone receptor beta-1	Target Info	Modulator	[544305]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Thyroid hormone signaling pathway
Pathway Interaction Database	RXR and RAR heterodimerization with other nuclear receptor
Reactome	Nuclear Receptor transcription pathway
WikiPathways	SIDS Susceptibility Pathways
	Hematopoietic Stem Cell Differentiation
	Nuclear Receptors
References
Ref 544305	Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors alpha-1 and beta-1. FEBS Open Bio. 2012; 2: 247-253.
Ref 544305	Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors alpha-1 and beta-1. FEBS Open Bio. 2012; 2: 247-253.

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