Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V5FQ
|
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| Former ID |
DIB005116
|
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| Drug Name |
Axitirome
|
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| Synonyms |
CGP-26214; CGS-25845; CGS-26214
|
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| Drug Type |
Small molecular drug
|
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| Indication | Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] | Phase 1 | [1] | ||
| Company |
Novartis AG
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C25H24FNO6
|
||||
| Canonical SMILES |
c1(C(c2ccc(cc2)F)O)c(ccc(Oc2c(cc(NC(=O)C(=O)OCC)cc2C)C)<br />c1)O
|
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| CAS Number |
CAS 156740-57-7
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Thyroid hormone receptor beta-1 | Target Info | Modulator | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Thyroid hormone signaling pathway | |||||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | ||||
| Reactome | Nuclear Receptor transcription pathway | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Hematopoietic Stem Cell Differentiation | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors alpha-1 and beta-1. FEBS Open Bio. 2012; 2: 247-253. | ||||
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