Drug Information

Drug General Information
Drug ID
D0V5OS
Former ID
DIB019993
Drug Name
H87/07
Synonyms
H 87-07
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540823]
Structure
Download
2D MOL
Formula
C15H25NO4
InChI
InChI=1S/C15H25NO4/c1-12(2)16-10-13(17)11-20-15-6-4-14(5-7-15)19-9-8-18-3/h4-7,12-13,16-17H,8-11H2,1-3H3
InChIKey
FGAPARDHTDKREN-UHFFFAOYSA-N
PubChem Compound ID
193122
PubChem Substance ID
14973066, 22395567, 24524123, 33513958, 52489334, 85209772, 103101018, 103383999, 113455100, 117535259, 125706201, 135169751, 135650344, 162833177, 163355725
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Antagonist [525440]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540823(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 542).
Ref 525440LK 204-545, a highly selective beta1-adrenoceptor antagonist at human beta-adrenoceptors. Eur J Pharmacol. 1999 Feb 19;367(2-3):431-5.

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