Drug Information

Drug General Information
Drug ID
D0V6IG
Former ID
DNC000019
Drug Name
(S)-WAY 100135
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538050]
Structure
Download
2D MOL

3D MOL
Formula
C24H33N3O2
Canonical SMILES
CC(C)(C)NC(=O)C(CN1CCN(CC1)C2=CC=CC=C2OC)C3=CC=CC=C3
InChI
1S/C24H33N3O2/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4/h5-13,20H,14-18H2,1-4H3,(H,25,28)
InChIKey
UMTDAKAAYOXIKU-UHFFFAOYSA-N
CAS Number
CAS 133025-23-7
PubChem Compound ID
115111
PubChem Substance ID
6769101, 10236637, 14756769, 29296661, 47731208, 47731209, 50020185, 57338998, 78007711, 85209853, 85788137, 103190079, 103978074, 104397613, 126671682, 129390641, 134224310, 134339570, 135073051, 135651320, 141444281, 144239582, 162224463, 164759069, 184538722, 223657926, 228358049
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [538050]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538050Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190. Pharmacol Biochem Behav. 1997 Oct;58(2):593-603.
Ref 538050Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190. Pharmacol Biochem Behav. 1997 Oct;58(2):593-603.

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