Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V6NX
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| Former ID |
DIB005822
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| Drug Name |
P2X7 antagonists
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| Synonyms |
P2X7 antagonists (pain); P2X7 antagonists (pain), GlaxoSmithKline
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| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Investigative | [1] | ||
| Company |
GlaxoSmithKline plc
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
N1([C@@H](CNC1=O)C(=O)NCc1c(cc(cc1)Cl)Cl)C
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| Target and Pathway | |||||
| Target(s) | P2X purinoceptor 7 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Reactome | The NLRP3 inflammasome | ||||
| WikiPathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | ||||
| References | |||||
| REF 1 | Paradoxical P2X7. Baas, T. SciBX 5(20). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 484). | ||||
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