Drug General Information
Drug ID	D0V7QA
Former ID	DNC013249
Drug Name	1,4-dihydroindeno[1,2-c]-pyrazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527858]
Structure		Download 2D MOL 3D MOL
Formula	C22H19Cl3N4O
Canonical SMILES	C1C2=CC=CC=C2C3=C1C=NN3
InChI	1S/C10H8N2/c1-2-4-9-7(3-1)5-8-6-11-12-10(8)9/h1-4,6H,5H2,(H,11,12)
InChIKey	DGYDIEIMGSEYDK-UHFFFAOYSA-N
PubChem Compound ID	44418727
Target and Pathway
Target(s)	Cannabinoid receptor 1	Target Info	Inhibitor	[527858]
	Cannabinoid receptor 2	Target Info	Inhibitor	[527858]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signalinghsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway	Endogenous cannabinoid signaling
Pathway Interaction Database	N-cadherin signaling events
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	BDNF signaling pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 527858	J Med Chem. 2005 Nov 17;48(23):7351-62.Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide.
Ref 527858	J Med Chem. 2005 Nov 17;48(23):7351-62.Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.