Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V8GX
|
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| Former ID |
DIB018934
|
||||
| Drug Name |
AZD8542
|
||||
| Synonyms |
AZD 8542; AZD-8542
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C25H24N4O2
|
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| InChI |
InChI=1S/C25H24N4O2/c1-17-12-18(2)23(13-22(17)24-14-29(3)16-27-24)28-25(30)19-7-9-21(10-8-19)31-15-20-6-4-5-11-26-20/h4-14,16H,15H2,1-3H3,(H,28,30)
|
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| InChIKey |
SMQVBAGSZVHCJP-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | smoothened receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Hedgehog signaling pathway | ||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| Basal cell carcinoma | |||||
| PANTHER Pathway | Hedgehog signaling pathway | ||||
| Pathway Interaction Database | Signaling events mediated by the Hedgehog family | ||||
| Hedgehog signaling events mediated by Gli proteins | |||||
| Reactome | Class B/2 (Secretin family receptors) | ||||
| Hedgehog 'off' state | |||||
| Activation of SMO | |||||
| WikiPathways | Hedgehog Signaling Pathway | ||||
| Hair Follicle Development: Organogenesis (Part 2 of 3) | |||||
| Hair Follicle Development: Induction (Part 1 of 3) | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| GPCR ligand binding | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. Mol Cancer Res. 2012 Sep;10(9):1147-57. Epub 2012 Aug 2. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 239). | ||||
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