Drug Information

Drug General Information
Drug ID
D0V8QT
Former ID
DAP000787
Drug Name
Chlorambucil
Synonyms
Ambochlorin; Amboclorin; Chlocambucil; Chloorambucol; Chlorambucilum; Chloraminophen; Chloraminophene; Chlorbutin; Chlorbutine; Chlorbutinum; Chloroambucil; Chlorobutin; Chlorobutine; Clorambucile; Clorambucilo; Ecloril; Elcoril; Elcorin; Leukeran; Leukersan; Leukoran; Linfolizin; Linfolysin; Lympholysin; Clorambucile [DCIT]; Glaxo Wellcome Brand of Chlorambucil; GlaxoSmithKline Brand of Chlorambucil; Leuk ersan; Leukeran tablets; Phenylbutyric acid nitrogen mustard; Wellcome Brand of Chlorambucil; C0253; CB 1348; CB1348; Cb l348; CB-1348; Chlorambucil [INN:BAN]; Chlorambucilum [INN-Latin]; Clorambucilo [INN-Spanish]; LEUKERAN (TN); Leukeran (TN); Phenylbuttersaeure-lost; Phenylbuttersaeure-lost[German]; Chlorambucil (USP/INN)
Drug Type
Small molecular drug
Indication Chronic lymphocytic leukaemia [ICD10:C91] Approved [538433], [542151]
Therapeutic Class
Anticancer Agents
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C14H19Cl2NO2
InChI
InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
InChIKey
JCKYGMPEJWAADB-UHFFFAOYSA-N
CAS Number
CAS 305-03-3
PubChem Compound ID
2708
PubChem Substance ID
9117, 69624, 611297, 855863, 3184022, 4963890, 7847332, 7886485, 7978915, 8149242, 8151754, 10517880, 11110896, 11110897, 11335863, 11361102, 11362972, 11365534, 11368096, 11371291, 11373905, 11376258, 11407032, 11462074, 11467107, 11468227, 11483985, 11486735, 11487881, 11490152, 11492088, 11493932, 11533216, 14825408, 17389986, 17404790, 24278287, 24853850, 26611647, 26680120, 26747014, 26747015, 26747016, 26747017, 29215014, 29221865, 46506842, 47216784, 47291145, 47515327
ChEBI ID
ChEBI:28830
SuperDrug ATC ID
L01AA02
SuperDrug CAS ID
cas=000305033
Target and Pathway
Target(s) DNA Target Info Intercalator [537444]
References
Ref 538433FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010669.
Ref 542151(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7143).
Ref 537444Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A. Mol Cancer Ther. 2009 Jun;8(6):1714-23. Epub 2009 Jun 9.

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