Drug General Information
Drug ID	D0V9HH
Former ID	DIB013145
Drug Name	Taprizosin
Synonyms	UK-338003
Drug Type	Small molecular drug
Indication	Prostate hyperplasia [ICD10:N40]		Discontinued in Phase 2	[547527]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Formula	C25H26N6O4S
Canonical SMILES	n1c(nc2c(c(c(c(c2)OC)OC)c2ncccc2)c1N)N1Cc2c(c(NS(=O)(=O<br />)C)ccc2)CC1
CAS Number	CAS 210538-44-6
PubChem Compound ID	6433102
Target and Pathway
Target(s)	Alpha-1A adrenergic receptor	Target Info	Antagonist	[528839]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	AMPK signaling pathway
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretion
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	AMPK Signaling
References
Ref 547527	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017098)
Ref 528839	Impact of physicochemical and structural properties on the pharmacokinetics of a series of alpha1L-adrenoceptor antagonists. Drug Metab Dispos. 2007 Aug;35(8):1435-45. Epub 2007 May 14.

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