Drug Information

Drug General Information
Drug ID
D0V9IE
Former ID
DNC001534
Drug Name
ZD2079
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Phase 2 [525938]
Structure
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2D MOL

3D MOL
Formula
C18H22ClNO4
Canonical SMILES
C1=CC=C(C=C1)C(CNCCOC2=CC=C(C=C2)CC(=O)O)O.Cl
InChI
1S/C18H21NO4.ClH/c20-17(15-4-2-1-3-5-15)13-19-10-11-23-16-8-6-14(7-9-16)12-18(21)22;/h1-9,17,19-20H,10-13H2,(H,21,22);1H/t17-;/m0./s1
InChIKey
KCEFVYIWOQSJCH-LMOVPXPDSA-N
CAS Number
CAS 107452-89-1
PubChem Compound ID
158793
PubChem Substance ID
10253428, 14900898, 17396869, 26753209, 46234171, 49878827, 57348545, 77298170, 113440827, 123120903, 135256627, 135698534, 144207136, 160677170, 162805159, 170466782, 172919613, 198947752, 224984088, 227461384, 241375792, 252156318
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [534855]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 525938Effects of the two beta3-agonists, ZD7114 and ZD2079 on 24 hour energy expenditure and respiratory quotient in obese subjects. Int J Obes Relat Metab Disord. 2000 Dec;24(12):1553-60.
Ref 534855Urinary tract toxicity in rats following administration of beta 3-adrenoceptor agonists. Toxicol Pathol. 1999 Mar-Apr;27(2):165-70.

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