Drug General Information
Drug ID
D0VI9P
Former ID
DIB000213
Drug Name
OPN-305
Synonyms
OPN-301; TLR-specific mAbs (inflammatory diseases), Opsona; Toll-like receptor specific monoclonal antibodies (inflammatory diseases), Opsona
Drug Type
Antibody
Indication Myelodysplastic syndrome [ICD9: 238.7; ICD10:D46] Phase 2 [524216]
Company
Opsona therapeutics
Target and Pathway
Target(s) Toll-like receptor 2 Target Info [531811]
KEGG Pathway Phagosome
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Measles
Herpes simplex infection
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
NetPath Pathway IL4 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signaling
Reactome Beta defensins
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
WikiPathways Toll-like receptor signaling pathway
IL1 and megakaryotyces in obesity
Human Complement System
Toll-Like Receptors Cascades
MyD88:Mal cascade initiated on plasma membrane
Defensins
Regulation of toll-like receptor signaling pathway
References
Ref 524216ClinicalTrials.gov (NCT01794663) Placebo-Controlled Study to Evaluate the Safety and Efficacy of OPN-305 in Preventing Delayed Renal Graft Function. U.S. National Institutes of Health.
Ref 531811Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs. Circ Cardiovasc Interv. 2012 Apr;5(2):279-87.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.